Nitric oxide (NO) synthase (iNOS) is required for the resolution of acute cutaneous
leishmaniasis in resistant C57BL/6 mice. As is the case in several other infections, the …

ABSTRACT Cytokine-inducible (or type 2) nitric oxide synthase (iNOS) is indispensable for
the resolution of Leishmania major or Leishmania donovani infections in mice. In contrast …

Previous studies with inhibitors of inducible nitric oxide synthase (iNOS) suggested that high-
output production of nitric oxide (NO) is an important antimicrobial effector pathway in vitro …

In the Leishmania major mouse model of cutaneous leishmaniasis inducible nitric oxide
synthase (iNOS) is crucial for the killing of the parasite in the skin and draining lymph node …

In vitro experiments suggest that cytokine induced nitric oxide (NO) synthesis from L-
arginine is a major effector mechanism against prokaryotic and eukaryotic intracellular …

Leishmania major infection in C57BL/6 mice is controlled by the activation of a Th1
response and nitric oxide (NO) production by macrophages. TNF‐α is considered one of the …

Cutaneous leishmaniasis affects millions of people around the world. Several species of
Leishmania infect mouse strains, and murine models closely reproduce the cutaneous …

Active human visceral leishmaniasis (VL) is characterized by a progressive increase in
visceral parasite burden, cachexia, massive splenomegaly, and hypergammaglobulinemia …

We have previously shown that mice lacking inducible NO synthase are markedly more
susceptible to Leishmania major infection but developed a significantly enhanced Th1 cell …

Nitric oxide (NO) production is critical for the host defense against intracellular pathogens;
however, it is unclear whether NO-dependent control of intracellular organisms depends on …