The human skin is exposed daily to different environmental factors such as air pollutants and
ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin …

Skin is the largest organ of the human body, having the purpose of regulating temperature,
protecting us from microbes or mechanical shocks, and allowing the sensations from touch …

The skin provides the primary protection for the body against external injuries and is
essential in the maintenance of general homeostasis. During ageing, resident cells become …

Skin ageing is the result of a loss of cellular function, which can be further accelerated by
external factors. Mitochondria have important roles in skin function, and mitochondrial …

Autophagy, or self-eating, is an evolutionarily conserved process in which cytosol and
organelles are sequestered within double-membrane vesicles that deliver the contents to …

Background Aging human skin undergoes significant morphological and functional changes
such as wrinkle formation, reduced wound healing capacity, and altered epidermal barrier …

As the most voluminous organ of the body that is exposed to the outer environment, the skin
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …

The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …

The skin is exposed to environmental insults such as UV light that cause oxidative damage
to macromolecules. A centerpiece in the defense against oxidative stress is the Nrf2 (nuclear …

Autophagy is a lysosome-dependent, self-renewal mechanism that can degrade and recycle
cellular components in eukaryotic cells to maintain the stability of the intracellular …