Skin is the largest organ of the body, and is prone to be affected by external environmental
factors. Skin aging is caused by both genetic and environmental factors. Furthermore, aging …

Macroautophagy/autophagy is a conserved degradation system that engulfs
intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for …

Everyone desires healthy and beautiful-looking skin. However, as we age, our skin becomes
old due to physiological changes. Reactive oxygen species (ROS) is an important …

There are two main processes that induce skin aging: intrinsic and extrinsic. A stochastic
process that implies random cell damage as a result of mutations during metabolic …

Macroautophagy/autophagy is a cellular catabolic process that is implicated in several
physiological and pathological processes. However, the role of epidermal autophagy in …

Autophagy and cellular senescence are stress responses essential for homeostasis. While
recent studies indicate a genetic relationship between autophagy and senescence, whether …

When mammalian cells and animals face a variety of internal or external stresses, they need
to make homeostatic changes so as to cope with various stresses. To this end, mammalian …

Our skin is an organ with the largest contact area between the human body and the external
environment. Skin aging is affected directly by both endogenous factors and exogenous …

Aging of the skin has fascinated researchers for decades not only to ultimately prevent
wrinkle formation, but also because the skin represents an excellent and accessible model …

In the current study, we have extended previous findings aiming at a better understanding of
molecular mechanisms underlying UVB-induced senescence of diploid human dermal …