Pharmacological and toxicological studies in neurodegeneration require comprehensive
behavioral analysis in mice because motor dysfunctions and dysfunctions in mood and …

Neuropsychiatric disorders are often associated with motor and coordination abnormalities
that have important implications on the etiology, pathophysiology, and management of these …

Locomotor activity can serve as a readout to identify discomfort and pain. Therefore,
monitoring locomotor activity following interventions that induce potential discomfort may …

Rodent models of brain disorders including neurodevelopmental, neuropsychiatric, and
neurodegenerative diseases are essential for increasing our understanding of underlying …

The behavioral characterization of animal models of psychiatric disorders is often based
upon independent traits measured at adult age. To model the neurodevelopmental aspects …

Motor function in humans can be characterized with tests of locomotion, strength, balance,
and endurance. The aim of our project was to establish an analogous test battery to assess …

Animal behavioral tests are essential to understand the bases of neurologic and
psychological disorders, which can be evaluated by different methodological and …

Many neurological and psychiatric disorders are characterized by deficits in cognitive
flexibility. Modeling cognitive flexibility in mice enables the investigation of mechanisms …

Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of
dementia. Hallmarks of AD are memory impairments and cognitive deficits, but non-cognitive …

Genetically modified mice are used to study the neurobiological basis of normal behavior
and have been developed as models of human neurodegenerative and psychiatric …