This study aimed to investigate the involvement of opioid receptors in the systemic and
peripheral antinociceptive activities of montelukast in different animal models of pain. Rats …

Objective The leukotrienes are inflammatory mediators. In the present study, the analgesic
role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible …

Background: Various inflammatory mediators are involved in initiating and sustaining
pain/inflammation cascade. Recently, leukotrienes (LTs) have been shown to be important …

Background Lysionotin, a natural flavonoid extracted from Lysionotus pauciflorus Maxim
(Gesneriaceae), has several pharmacological effects including anti-bacterial, anti …

The antinociceptive effect of intracerebroventricular injections of [2–8]-leucopyrokinin (LPK),
a truncated leucopyrokinin analogue, was determined in rats, by means of a tail immersion …

This study investigated the antinociceptive effects of zerumbone in chemical behavioural
models of nociception in mice. Zerumbone given through intraperitoneal route (ip) produced …

In the present study, we determined the potential anti-nociceptive activity of vitexin, a C-
glycosylated flavone, by conducting some acute nociceptive tests in mice. Centrally …

OBJECTIVES: The objective of this study was to examine the nature of interaction between
cyclooxygenase-2 inhibitor meloxicam and inducible nitric oxide synthase inhibitor …

Context: Homoeriodictyol is a flavonoid with known antioxidant, anti-inflammatory, and anti-
tumor properties found in various plants. However, its potential analgesic effects have not …

Background The analgesic properties and mechanisms of loperamide hydrochloride, a
peripherally acting opioid receptor agonist, in neuropathic pain warrant further investigation …