Many anticancer agents exert cytotoxicity and trigger apoptosis through the induction of
mitochondrial dysfunction. Mitophagy, as a key mitochondrial quality control mechanism …

Mitochondria as a signaling platform play crucial roles in deciding cell fate. Many classic
anticancer agents are known to trigger cell death through induction of mitochondrial …

Autophagy is mainly a cellular recycling process that promotes survival, but it can also cause
cell death if cell injury persists. The role of mitophagy in tumorigenesis remains uncertain …

Mitophagy is a type of selective macroautophagy/autophagy that degrades dysfunctional or
excessive mitochondria. Regulation of this process is critical for maintaining cellular …

The effectiveness of chemotherapy is largely limited by drug resistance. In the past few
decades, modulation of anticancer drug resistance plays little role in benefit of clinical …

Mitophagy is a selective form of macroautophagy in which dysfunctional and damaged
mitochondria can be efficiently degraded, removed and recycled through autophagy …

Background Mitophagy refers to the selective self‐elimination of mitochondria under
damaged or certain developmental conditions. As an important regulatory mechanism to …

The mitochondrion is an organelle that plays a vital role in energy production, cytoplasmic
protein degradation and cell death. Mitophagy is an autophagic procedure that specifically …

Loss-of-function mutations in PINK1 or PARKIN are associated with early-onset Parkinson's
disease. Upon mitochondrial stress, PINK1 and Parkin together mediate a response that …

Molecules designed to target and accumulate in the mitochondria are an emerging
therapeutic approach for cancer and other indications. Mitochondria-targeted redox agents …