The neurophysiological mechanisms by which anesthetic drugs cause loss of
consciousness are poorly understood. Anesthetic actions at the molecular, cellular, and …

The mechanism (s) by which anesthetics reversibly suppress consciousness are
incompletely understood. Previous functional imaging studies demonstrated dynamic …

The mechanisms underlying anesthesia-induced loss of consciousness remain a matter of
debate. Recent electrophysiological reports suggest that while initial propofol infusion …

The richness of conscious experience is thought to scale with the size of the repertoire of
causal brain states, and it may be diminished in anesthesia. We estimated the state …

Although the molecular effects of many anaesthetics have been well characterized, a
network-level explanation for how these changes lead to loss of consciousness remains …

General anesthesia (GA) is a reversible drug-induced state of altered arousal required for
more than 60,000 surgical procedures each day in the United States alone. Sedation and …

Applying graph theoretical analysis of spontaneous BOLD fluctuations in functional
magnetic resonance imaging (fMRI), we investigated whole-brain functional connectivity of …

During propofol-induced general anesthesia, alpha rhythms measured using
electroencephalography undergo a striking shift from posterior to anterior, termed …

The neural mechanisms of anesthetic-induced unconsciousness have yet to be fully
elucidated, in part because of the diverse molecular targets of anesthetic agents. We …

General anesthetics induce loss of consciousness, a global change in behavior. However, a
corresponding global change in activity in the context of defined cortical cell types has not …