Cholinesterase inhibition is of great importance in the fight against neurodegenerative
disorders such as Alzheimer's disease. Azole antifungals have come under the spotlight with …

Recent advances in cholinesterase inhibitors opened new venues for the treatment of
cognitive disorders like Alzheimer's disease. Certain azole antifungals like miconazole were …

An important research topic is the discovery of multifunctional compounds targeting different
disease-causing components. This research aimed to design and synthesize a series of 2 …

Alzheimer's disease (AD) is a chronic disease that is multifactorial. Its underlying cause and
mechanisms are yet to be fully understood and numerous research are underway to develop …

Due to the rising prevalence of Alzheimer's disease (AD), there is a pressing need for more
effective drugs to treat or manage AD's symptoms. Studies have shown that cholinesterase …

In a continuation of our previous work for the exploration of novel enzyme inhibitors, two new
coumarin-thiazole 6 (a–o) and coumarin-oxadiazole 11 (a–h) hybrids have been designed …

Acetylcholinesterase and butyrylcholinesterase enzymes are therapeutic target for
Alzheimer disease and their inhibitors play a vital role for the treatment of this disease. A …

Abstract Alzheimer's dementia (AD), the most prevalent neurodegenerative disorder
adversely affecting elderly citizens worldwide, is an incurable disorder with no effective …

Discovering new compounds capable of inhibiting physiologically and metabolically
significant drug targets or enzymes is of paramount importance in biological chemistry. With …

Aim: Current study aims exploration of bis-benzoxazole bearing bis-Schiff base scaffolds (1–
16) as anti-Alzheimer's agents. Materials & methods: 2-aminophenol is used as starting …