The purpose of our study was to assess the influence of lactation stage–dependent
differences in milk-to-serum (M/S) ratio for an actively transported drug (cefepime) on the …

Background: Very little is known about the level of infant exposure to many drugs commonly
used during breastfeeding. The aim of this study was to develop a physiologically-based …

Background: Drug prescriptions are usual during pregnancy, however, women and their
fetuses still remain an orphan population with regard to drugs efficacy and safety. Most …

Knowledge of pharmacokinetics and the use of a mechanistic-based approach can improve
our ability to predict the effects of pregnancy for medications when data are limited. Despite …

Background Fetal blood and plasma volume and binding components are critical
parameters in a fetal physiologically based pharmacokinetic model. To date, a …

There are many benefits of breast-feeding both for the infant and for the mother. Nursing
mothers who are also taking medications or exposed to environmental hazards may be …

Excipients are frequently used to facilitate the manufacture and storage of medicines.
Pharmacological effects and adverse events can be attributed to excipients. Examples in …

The developmental origin of health and diseases theory supports the critical role of the fetal
exposure to children's health. We developed a physiologically based pharmacokinetic …

In recent years efforts have increased to develop a framework for assessing differences,
both pharmacokinetic and pharmacodynamic, between children and adults for purposes of …

Determining fetal drug exposure (except at the time of birth) is not possible for both logistical
and ethical reasons. Therefore, we developed a novel maternal-fetal physiologically based …