We studied the effects of extremely low-dose human renin inhibition (aliskiren) with low
angiotensin II receptor blockade (losartan) in a novel double-transgenic rat model …

We tested the hypothesis that the renin inhibitor aliskiren ameliorates organ damage in rats
transgenic for human renin and angiotensinogen genes (double transgenic rat [dTGR]). Six …

Introduction Controlling hypertension by angiotensin converting enzyme inhibitors (ACEI) or
angiotensin receptor blockers (ARB), mechanisms that inhibit later pathway steps in the …

The role of the renin-angiotensin system in chronic kidney disease involves multiple
peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition …

Several cardiac and renal diseases are attributed to a dysregulation of the renin-angiotensin
system. Renin, the rate-limiting enzyme of the renin-angiotensin system, has 2 isoforms. The …

Aliskiren, a direct renin inhibitor, is a novel antihypertensive drug. To study whether aliskiren
can reverse chronic kidney disease, we administered it to renin transgenic mice, a strain …

Abstract The Joint National Committee and the World Health Organization are in agreement
that hypertension in most patients who are treated is controlled inadequately and that rates …

Introduction This study was performed to determine whether chronic direct renin inhibition
can prevent the development of slowly progressive angiotensin (ANG) II-dependent …

Abstract Introduction Cyp1a1-Ren2 transgenic rats [strain name: TGR (Cyp1a1Ren2)],
administered indole-3-carbinol (I3C) develop angiotensin (ANG) II-dependent hypertension …

Objective In the present study we compared the effects of treatment with the AT 1 receptor
antagonist candesartan and of 'triple therapy'(hydralazine, hydrochlorothiazide, reserpine) …