[HTML][HTML] Design, synthesis, bio-evaluation, and in silico studies of some N-substituted 6-(chloro/nitro)-1 H-benzimidazole derivatives as antimicrobial and anticancer …

EC Pham, TVT Le, TN Truong - RSC advances, 2022 - pubs.rsc.org
A new series of 6-substituted 1H-benzimidazole derivatives were synthesized by reacting
various substituted aromatic aldehydes with 4-nitro-o-phenylenediamine and 4-chloro-o …

[HTML][HTML] N, 2, 6-Trisubstituted 1 H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in …

EC Pham, TV Le Thi, HHL Hong, BNV Thi, LB Vong… - RSC …, 2023 - pubs.rsc.org
Compounds containing benzimidazole moiety occupy privileged chemical space for
discovering new bioactive substances. In continuation of our recent work, 69 benzimidazole …

[HTML][HTML] Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial …

D Sharma, S Kumar, B Narasimhan, K Ramasamy… - BMC chemistry, 2019 - Springer
To combat the antimicrobial and anticancer drug resistance by pathogens and cancerous
cells, efforts has been made to study the pharmacological activities of newly synthesized N …

Synthesis, structure‐activity relationship and in silico studies of novel pyrazolothiazole and thiazolopyridine derivatives as prospective antimicrobial and anticancer …

IMM Othman, MAM Gad‐Elkareem… - …, 2021 - Wiley Online Library
In our attempt to develop potential new drug candidates with promising dual antimicrobial
and anticancer activities, a series of pyrazolothiazole and thiazolopyridine analogues has …

Synthesis, anti-HIV, antimicrobial evaluation and structure activity relationship studies of some novel benzimidazole derivatives

G Yadav, S Ganguly, S Murugesan… - Anti-infective agents, 2015 - ingentaconnect.com
In this study 26 novel benzimidazole compounds bearing alkyl chain as linker at N-1
position were synthesized and evaluated to investigate their possible anti-HIV and …

Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents

MM Morcoss, MN El Shimaa, RA Ibrahem… - Bioorganic …, 2020 - Elsevier
Herein, novel three series of benzimidazole scaffold bearing hydrazone, 1, 2, 4-triazole and
1, 3, 4-oxadiazole moieties 1-3, 4a-j, 6a-c and 7 derivatives were designed, synthesized and …

Synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents

NS El-Gohary, MI Shaaban - European journal of medicinal chemistry, 2017 - Elsevier
New benzimidazole derivatives were synthesized and assessed for antimicrobial efficacy
toward Escherichia coli, Bacillus cereus, Staphylococcus aureus, Candida albicans and …

Synthesis, Anticancer Activity, and In Silico Modeling of Alkylsulfonyl Benzimidazole Derivatives: Unveiling Potent Bcl-2 Inhibitors for Breast Cancer

Y Abbade, MM Kisla, MAK Hassan, I Celik… - ACS …, 2024 - ACS Publications
A series of alkylsulfonyl 1 H-benzo [d] imidazole derivatives were synthesized and evaluated
for anticancer activity against human breast cancer cells, MCF-7 in vitro. The cytotoxic …

Design, synthesis, SAR study, antimicrobial and anticancer evaluation of novel 2-mercaptobenzimidazole azomethine derivatives

S Tahlan, B Narasimhan, SM Lim… - mini reviews in …, 2020 - ingentaconnect.com
Background: Various analogues of benzimidazole are found to be biologically and
therapeutically potent against several ailments. Benzimidazole when attached with …

[HTML][HTML] 4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile

D Sharma, S Kumar, B Narasimhan, K Ramasamy… - BMC chemistry, 2019 - Springer
In order to overcome the challenges of microbial resistance as well as to improve the
effectiveness and selectivity of chemotherapeutic agents against cancer, a novel series of 4 …