Cytochrome P450s comprise a superfamily of heme-thiolate proteins named for the spectral
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …

The superfamily of heme-thiolate proteins known as the cytochromes P450 is responsible for
the oxidative metabolism of the majority of drugs. Thus, the phenotypes of individuals with …

The human cytochrome P450 (CYP) complement of heme-thiolate enzymes is reviewed. Of
the 57 individual P450s characterized in Homo sapiens thus far, it is apparent that …

Human cytochrome P450 (CYP) enzymes are widely known for their pivotal role in the
metabolism of drugs and other xenobiotics as well as of endogenous chemicals. In addition …

Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …

This review focuses on the structural models for cytochrome P450, which are improving our
knowledge and understanding of the P450 catalytic cycle, and the way in which substrates …

Many members of the superfamily of hemeproteins, known as cytochrome P450 (P450 or
CYP), are currently described in the literature (over 2000 at the date of this writing)[see …

Over the past decade, site-directed mutagenesis has become an essential tool in the study
of mammalian cytochrome P450 structure-function relationships. Residues affecting …

Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a
review that summarizes the current state of research in the field of drug metabolism. The …

The Cytochrome P450 super-family is a fundamental requirement for the viability of most life,
with Cytochrome P450 proteins having been identified in organisms ranging from bacteria to …