Abstract Learning Objectives After completing this course, the reader will be able to:
Compare and contrast the mechanism of action for angiogenesis inhibitors currently being …

Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a central
role in the process of tumor growth and metastasis. The proliferation of endothelium and …

The vascular endothelial growth factor (VEGF) family of polypeptide growth factors regulates
a family of VEGF receptor (VEGFR) tyrosine kinases with pleiotropic downstream effects …

Multiple cellular pathways influence the growth and metastatic potential of tumors. This
creates heterogeneity, redundancy, and the potential for tumors to bypass signaling pathway …

Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
the mechanism of action of tyrosine kinase inhibitors of VEGFRs that are in clinical trials …

Tumours require a vascular supply to grow and can achieve this via the expression of pro-
angiogenic growth factors, including members of the vascular endothelial growth factor …

Receptor tyrosine kinases (RTK), such as vascular endothelial growth factor receptor
(VEGFR), platelet-derived growth factor receptor (PDGFR), stem cell factor receptor (KIT) …

VEGFR inhibitors are in broad use for the treatment of metastatic renal-cell carcinoma,
gastrointestinal stromal tumors and hepatocellular carcinoma and in development in a …

The vascular endothelial growth factor (VEGF) signaling pathway appears to be the
dominant pathway involved in tumor angiogenesis, providing a rationale for targeting the …

New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …