New blood vessel formation (angiogenesis) is fundamental to the process of tumor growth,
invasion, and metastatic dissemination. The vascular endothelial growth factor (VEGF) …

Among the known angiogenic growth factors and cytokines implicated in the modulation of
normal and pathological angiogenesis, the VEGF family (VEGF-A, VEGF-B, VEGF-C, VEGF …

Vascular Endothelial Growth Factor (VEGF) is considered to be one of the most important
regulators of angiogenesis and a new key target in anti-cancer treatment. Various clinical …

The vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor
(VEGFR) axis is indispensable in the process of angiogenesis and has been implicated as a …

Angiogenesis plays an important role in the formation of new blood vessels and is crucial for
tumour development and progression. Imbalance between pro-and antiangiogenesis factors …

Angiogenesis, or the formation of new capillary blood vessels, occurs primarily during
human development and reproduction; however, aberrant regulation of angiogenesis is also …

The last decade has witnessed the approval of monoclonal antibodies (mAbs) and small
molecule tyrosine kinase inhibitors (TKIs) for targeting of oncogenic signaling pathways …

Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) have crucial roles in
both physiological and pathological angiogenesis. The VEGF family consists of VEGF-A …

Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Tumor angiogenesis is a degenerate process regulated by a complex network of
proangiogenic factors. Existing antiangiogenic drugs used in clinic are characterized by …