Abstract Image Functional Modeling (IFM) synthesizes three dimensional airway networks
with imaging and mechanics data to relate structure to function. The goal of this study was to …

Lung protective ventilation in Acute Lung Injury (ALI) focuses on using low tidal volumes and
adequate levels of positive end-expiratory pressure (PEEP). Identifying optimal pressure is …

Parenchymal strain is a key determinant of lung injury produced by mechanical ventilation.
However, imaging estimates of volumetric tidal strain (ε= regional tidal volume/reference …

Management of patients with acute lung injury (ALI) rests on achieving a balance between
the gas exchanging benefits of mechanical ventilation and the exacerbation of tissue …

Goal: Ventilated patients with the acute respiratory distress syndrome (ARDS) are
predisposed to cyclic parenchymal overdistention and derecruitment, which may worsen …

Background Potentially harmful lung overstretch can follow intraparenchymal gas
redistribution during mechanical ventilation. We hypothesized that inspiratory efforts …

Background Positive end-expiratory pressure (PEEP) individualized to a maximal respiratory
system compliance directly implies minimal driving pressures with potential outcome …

Heterogeneity in regional end expiratory lung volume (EELV) may lead to variations in
regional strain (ε). High ε levels have been associated with ventilator‐associated lung injury …

VENTILATION HETEROGENEITY is an established marker of pulmonary dysfunction in
asthma and other conditions such as acute respiratory distress syndrome (ARDS) and …

BACKGROUND: Esophageal pressure measurement for computation of transpulmonary
pressure (Ptp) has begun to be incorporated into clinical use for evaluating forces across the …