Fungal diseases represent a major burden to health care globally. As with other pathogenic
microbes, there is a limited number of agents suitable for use in treating fungal diseases …

Cryptococcus neoformans is responsible for over 100 000 deaths annually, and the
treatment of this fungal disease is expensive and not consistently effective. Unveiling new …

Cryptococcal meningoencephalitis is the most common fungal disease in the central
nervous system. The mechanisms by which Cryptococcus neoformans invades the brain are …

Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

In recent decades, the incidence of Cryptococcus neoformans infection, which causes
cryptococcosis, has consistently increased. Fluconazole (FLU) is frequently used in the …

Cryptococcus neoformans is an encapsulated yeast-like fungus capable of causing life
threatening meningoencephalitis in patients with impaired immunity. This microbe primarily …

Pathogenic fungus Cryptococcus neoformans has a predilection for the central nervous
system causing devastating meningoencephalitis. Traversal of C. neoformans across the …

Cryptococcus neoformans can invade the central nervous system through diverse
mechanisms. We examined a possible role for host plasma proteases in the neurotropic …

Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in
patients with HIV infection. The antifungal pharmacological treatment is limited to …

Cryptococcus neoformans causes lethal meningitis and accounts for approximately 10%–
15% of AIDS-associated deaths worldwide. There are major gaps in our understanding of …