The interaction of pathogenic Cryptococcus species with their various hosts is somewhat
unique compared to other fungal pathogens such as Aspergillus fumigatus and Candida …

Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

Systemic infection with Cryptococcus neoformans, a dangerous and contagious pathogen
found throughout the world, frequently results in lethal cryptococcal pneumonia and …

Pathogenic cryptococci are encapsulated yeast that can cause severe meningoencephalitis.
Existing therapeutic options are dated and there is a growing need for new alternative …

Cryptococcal meningitis, caused by the fungal pathogen Cryptococcus neoformans, is a
devastating disease with a mortality rate of over 80%. Due to the increasing prevalence of …

Background Emerging fungal pathogens pose important threats to global public health. The
World Health Organization has responded to the rising threat of traditionally neglected …

The fungal pathogen Cryptococcus neoformans has a predilection for the central nervous
system (CNS), resulting in devastating meningoencephalitis. At present, it is unclear how C …

Cryptococcus neoformans is a basidiomycetous yeast responsible for hundreds of
thousands of deaths a year and is particularly threatening in immunocompromised patients …

Multiple isolates of Cryptococcus neoformans were tested to compare the in vitro activity of a
new triazole, SCH56592, with those of amphotericin B, fluconazole, and itraconazole, MICs …

Cryptococcal Meningitis (CM) is uniformly fatal if not treated, and treatment options are
limited. We previously reported on the activity of APX2096, the prodrug of the novel Gwt1 …