Cryptococcus neoformans infection is an important cause of meningitis in HIV/AIDS endemic
regions. Antifungals for its management include amphotericin B, flucytosine, and …

Many infectious diseases disproportionately affect people in the developing world.
Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the …

There is an urgent unmet need for novel antifungals. In this study, we searched for novel
antifungal activities in the Pandemic Response Box, a collection of 400 structurally diverse …

ABSTRACT The casein kinase 2 (CK2) complex has garnered extensive attention over the
past decades as a potential therapeutic target for diverse human diseases, including cancer …

Cryptococcus neoformans is an opportunistic fungus responsible for severe and often
recurrent meningoencephalitis in immunodepressed patients. Initial evidence suggests that …

Aantifungal agents were tested against 30 clinical isolates of Cryptococcus neoformans var.
neoformans using the NCCLS method (M27-A2). Posaconazole, itraconazole and …

ABSTRACT VT-1129 is a novel fungal enzyme-specific Cyp51 inhibitor with potent
cryptococcal activity. Because of its long half-life (> 6 days in mice) and our desire to quickly …

Proliferation and host evasion are critical processes to understand at a basic biological level
for improving infectious disease treatment options. The human fungal pathogen …

Cryptococcus neoformans and Cryptococcus gatti are the etiological agents of
cryptococcosis, a life-threatening mycosis affecting the central nervous system. Cryptococcal …

Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and
outcome. As in many infectious diseases, this variability is commonly assigned to host …