Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization
LE Wicki-Stordeur, AKJ Boyce… - Cell communication & …, 2013 - Taylor & Francis
Pannexins (Panxs) are a three-member family of large pore ion channels permeable to ions
and small molecules. Recent elegant work has demonstrated that the Panx1 C-terminus …
and small molecules. Recent elegant work has demonstrated that the Panx1 C-terminus …
Pore positioning: current concepts in Pannexin channel trafficking
Pannexins (Panxs) are a multifaceted family of ion and metabolite channels that play key
roles in a number of physiological and pathophysiological settings. These single membrane …
roles in a number of physiological and pathophysiological settings. These single membrane …
[HTML][HTML] A novel motif in the proximal C-terminus of Pannexin 1 regulates cell surface localization
AL Epp, SN Ebert, JC Sanchez-Arias… - Scientific reports, 2019 - nature.com
Abstract The Pannexin 1 (Panx1) ion and metabolite channel is expressed in a wide variety
of cells where it regulates a number of cell behaviours including proliferation and …
of cells where it regulates a number of cell behaviours including proliferation and …
[HTML][HTML] Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain
Pannexin1 (Panx1) is an integral membrane protein comprised of three species as follows:
an unglycosylated core-Gly0, a high mannose-Gly1, and a complex glycosylated Gly2 …
an unglycosylated core-Gly0, a high mannose-Gly1, and a complex glycosylated Gly2 …
[HTML][HTML] N-glycosylation regulates pannexin 2 localization but is not required for interacting with pannexin 1
RE Sanchez-Pupo, D Johnston, S Penuela - International Journal of …, 2018 - mdpi.com
Pannexins (Panx1, 2, 3) are channel-forming glycoproteins expressed in mammalian
tissues. We previously reported that N-glycosylation acts as a regulator of the localization …
tissues. We previously reported that N-glycosylation acts as a regulator of the localization …
The cellular life of pannexins
The mammalian pannexin family of channel‐forming proteins consisting of Panx1, Panx2,
and Panx3 has received considerable attention in the last 10 years given their newly …
and Panx3 has received considerable attention in the last 10 years given their newly …
Diverse post-translational modifications of the pannexin family of channel-forming proteins
The pannexin family of channel-forming proteins is composed of 3 distinct but related
members called Panx1, Panx2, and Panx3. Pannexins have been implicated in many …
members called Panx1, Panx2, and Panx3. Pannexins have been implicated in many …
[HTML][HTML] Differential activation of mouse and human Panx1 channel variants
Pannexins are ubiquitously expressed in human and mouse tissues. Pannexin 1 (Panx1),
the most thoroughly characterized member of this family, forms plasmalemmal membrane …
the most thoroughly characterized member of this family, forms plasmalemmal membrane …
[HTML][HTML] The emerging Pannexin 1 signalome: a new nexus revealed?
LE Wicki-Stordeur, LA Swayne - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Pannexins (Panxs) are a family of single-membrane, large-pore ion, and metabolite
permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied …
permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied …
Structures of human pannexin 1 reveal ion pathways and mechanism of gating
Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …
physiological functions such as blood pressure regulation, apoptotic cell clearance and …