J. Neurochem.(2011) 118, 939–957. Abstract Alterations of iron levels in the brain has been
observed and documented in a number of neurodegenerative disorders including …

Objectives: Parkinson's disease (PD) afflicts approximately 1–2% of the population over 50
years of age. No cures or effective modifying treatments exist and clinical diagnosis is …

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal degenerative disorder of motor
neurons. The cause of this degeneration is unknown, and different causal hypotheses …

Valcamonica is an Italian valley where ferro-manganese industries have been active for a
century and where an increased prevalence of parkinsonism was observed. A group of 93 …

A plethora of environmental risk factors has been persistently implicated in the pathogenesis
of amyotrophic lateral sclerosis (ALS), including metal/metalloids. This study aimed to …

Previously we have shown that cell death in the substantia nigra (SN) in Parkinson's disease
(PD) is associated with an increase in iron content but a decrease in the level of the iron …

Abstract Background In Parkinson's disease (PD), impairment of brain to blood barrier
and/or blood-cerebrospinal fluid (CSF) barrier is described. It can increase the level of …

Objective The quantitative susceptibility mapping (QSM) technique was used to analyze the
distribution pattern of iron deposition in the basal ganglia region of patients with motor …

Mounting evidences indicated that elevated iron levels in the substantia nigra (SN) have
been concerned as the underlying mechanisms of neurodegenerative diseases, including …

Brain iron has been previously found elevated in the substantia nigra pars compacta (SNpc),
but not in other brain regions, of Parkinson's disease (PD) patients. However, iron in …