Purpose Abnormal platelet activation plays an important role in the development of sepsis.
The effect of antiplatelet drugs on the outcome of patients with sepsis remains unclear. This …

Background. Sepsis is characterized by dysfunctional activation of platelets, and antiplatelet
therapy could improve the outcomes of septic patients. Methods. We performed a …

Purpose Sepsis is a major health burden worldwide. Preclinical investigations in animals
and retrospective studies in patients have suggested that inhibition of platelets may improve …

Platelet activation plays an important role in the development of sepsis. During sepsis,
platelet activation leads to endothelial cell injury and promotes neutrophil extracellular trap …

Background Antiplatelet therapy may attenuate the undesirable effects of platelets on the
inflammatory cascades in critical illness. The objective of this study was to evaluate the …

As mechanisms of sepsis pathophysiology have been elucidated with time, sepsis may be
considered nowadays, as an uncontrolled inflammatory and pro-coagulant response to a …

Antiplatelet therapy is an attractive treatment option for critically ill patients. However, more
evidence on the benefit of this therapy is required. We searched the PubMed and Embase …

BACKGROUND: Aspirin has anti-inflammatory and antiplatelet activities and directly inhibits
bacterial growth. These effects of aspirin may improve survival in patients with sepsis. We …

Background Antiplatelet agents are widely used for cardiovascular disea ses, but their
pleiotropic effects in sepsis are controversial. Objective To investigate the association …

Platelet activation has been implicated in microvascular thrombosis and organ failure in
critically ill patients. In the first part the present paper summarises important data on the role …