[HTML][HTML] Nitric-oxide synthase trafficking inducer is a pleiotropic regulator of endothelial cell function and signaling

S Chakraborty, R Ain - Journal of Biological Chemistry, 2017 - ASBMB
Endothelial nitric-oxide synthase (eNOS) and its bioactive product, nitric oxide (NO), mediate
many endothelial cell functions, including angiogenesis and vascular permeability. For …

NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase

K Zimmermann, N Opitz, J Dedio… - Proceedings of the …, 2002 - National Acad Sciences
Activity and localization of endothelial nitric oxide synthase (eNOS) is regulated in a
remarkably complex fashion, yet the complex molecular machinery mastering stimulus …

Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3 …

ME McCormick, R Goel, D Fulton, S Oess… - … , and vascular biology, 2011 - Am Heart Assoc
Background—NO produced by the endothelial NO synthase (eNOS) is an important
regulator of cardiovascular physiological and pathological features. eNOS is activated by …

[HTML][HTML] Endothelial cell-specific loss of eNOS differentially affects endothelial function

S Bu, HC Nguyen, S Nikfarjam, DCR Michels… - PLoS …, 2022 - journals.plos.org
The endothelium maintains and regulates vascular homeostasis mainly by balancing
interplay between vasorelaxation and vasoconstriction via regulating Nitric Oxide (NO) …

Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells

PJ Kuhlencordt, E Rosel, RE Gerszten… - … of Physiology-Cell …, 2004 - journals.physiology.org
The objective of this study was to determine whether absence of endothelial nitric oxide
synthase (eNOS) affects the expression of cell surface adhesion molecules in endothelial …

NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS

A Icking, S Matt, N Opitz, A Wiesenthal… - Journal of Cell …, 2005 - journals.biologists.com
Intracellular trafficking of endothelial nitric oxide synthase (eNOS) between different
compartments is incompletely understood. Recently, we described a novel eNOS-interacting …

[HTML][HTML] Functional significance of cytosolic endothelial nitric-oxide synthase (eNOS): regulation of hyperpermeability

FA Sánchez, R Rana, FG González, T Iwahashi… - Journal of Biological …, 2011 - ASBMB
Endothelial NOS (eNOS)-derived NO is a key factor in regulating microvascular
permeability. We demonstrated previously that eNOS translocation from the plasma …

Endothelial nitric oxide synthase in the microcirculation

X Shu, TCS Keller, D Begandt, JT Butcher… - Cellular and molecular …, 2015 - Springer
Endothelial nitric oxide synthase (eNOS, NOS3) is responsible for producing nitric oxide
(NO)—a key molecule that can directly (or indirectly) act as a vasodilator and anti …

Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium

JE Fish, PA Marsden - Cellular and Molecular Life Sciences CMLS, 2006 - Springer
The vascular endothelium plays a crucial role in regulating normal blood vessel physiology.
The gene products responsible are commonly expressed exclusively, or preferentially, in …

Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton

M Schleicher, F Brundin, S Gross… - … and cellular biology, 2005 - Taylor & Francis
Nitric oxide (NO) plays a key role in vascular function, cell proliferation, and apoptosis.
Proper subcellular localization of endothelial NO synthase (eNOS) is crucial for its activity; …