The mechanism by which nitric-oxide (NO) production increases during hypoxia is unknown.
To explore the effect of hypoxia upon endothelial nitric-oxide synthase (ecNOS) activity and …

Endothelium-derived nitric oxide (NO) is an important regulator of vascular function. NO is
produced by endothelial NO synthase (eNOS) whose function is modulated, in part, by …

To elucidate the role of endothelial NO synthase (eNOS)-derived NO during mammalian
embryogenesis, we assessed the expression of the eNOS gene during development. Using …

Respiratory epithelium expresses nitric oxide synthase 2 (NOS2) continuously in vivo;
however, mechanisms responsible for its expression are only partially understood. We …

Endothelium-derived nitric oxide (NO) and its precursor l-arginine have been implied to
promote angiogenesis, but little is known about the precise mechanism. The inhibition of …

A healthy endothelium prevents the development of atherosclerosis through protective
effects on vasomotion, platelet adhesion, leukocyte trafficking, anti-inflammatory and anti …

In this study, we explore the roles of the delta isoform of PKC (PKCδ) in the regulation of
endothelial nitric oxide synthase (eNOS) activity in pulmonary arterial endothelial cells …

2498 MARON BA et al. tion of eNOS is dynamically regulated9 and the enzyme is thus
exposed to different concentrations of ROS depending upon where in the cell the protein is …

Pulmonary arterial hypertension (PAH) is a progressive disease arising from remodeling
and narrowing of pulmonary arteries (PA) resulting in high pulmonary arterial blood …

The family of nitric oxide synthases (NOS) has significant importance in various
physiological mechanisms and is also involved in many pathological processes. Three NOS …