Background and objectives Hereditary spastic paraplegias (HSPs) are heterogenous
genetic disorders. While peripheral nerve involvement is frequent in spastic paraplegia 7 …

Hereditary spastic paraplegias (HSP) have turned out to be an extremely challenging group
of genetic conditions. 1 Their heterogeneity is astonishing, with mutations in over 80 genes …

Abstract Introduction Hereditary Spastic Paraplegia (HSP) represents a complex and
heterogeneous group of rare neurodegenerative disorders that share a common clinical …

Objective: To identify structural white matter alterations in patients with pure hereditary
spastic paraplegia (HSP) using high angular resolution diffusion tensor imaging (DTI) …

Hereditary spastic paraplegia (HSP) is a group of genetically-determined disorders
characterized by progressive spasticity and weakness of lower limbs. An apparently …

The syndromic group of hereditary spastic paraplegias has a heterogeneous clinical profile
and a broad differential diagnosis, including neurometabolic disorders that are potentially …

Introduction The Hereditary Spastic Paraplegias (HSP) are a group of genetic diseases that
lead to slow deterioration of locomotion. Clinical scales seem to have low sensitivity in …

SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP) caused by
mutations in the SPAST gene. HSP is considered an upper motor neuron disorder …

The hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurologic
disorders with the common feature of prominent lower-extremity spasticity, resulting from a …

To determine the cortical mechanism that underlies the cognitive impairment and motor
disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family …