Aims The hereditary spastic paraplegias (HSPs) are a heterogeneous group of inherited
neurodegenerative disorders. Although, several genotype–phenotype studies have carried …

Background Molecular diagnosis of hereditary spastic paraplegias (HSP) is a difficult task
due to great clinical and genetic heterogeneity. We aimed to characterize clinical and …

Hereditary spastic paraparesis (HSP) is a heterogeneous group of neurodegenerative
disorders with progressive lower limb spasticity, categorized into pure (p‐HSP) and …

Hereditary spastic paraplegia (HSP) is a group of neurodegenerative disorders
characterized by progressive bilateral lower limb weakness and spasticity. In addition, HSP …

Abstract Introduction Hereditary spastic paraplegias (HSPs), a genetically heterogeneous
group of neurodegenerative diseases, have an incidence of around 3 to 9 individuals every …

Hereditary spastic paraplegia (HSP) is a group of familial diseases characterized by
progressive corticospinal tract degeneration. Clinically, patients present with lower‐limb …

Molecular characterization is important for an accurate diagnosis in hereditary spastic
paraplegia (HSP). Mutations in the gene SPAST (SPG4) are the most common cause of …

The authors have constructed a brief timeline of major clinical research related to hereditary
spastic paraplegia (HSP). This timeline summarizes the evolution of HSP research, from the …

Hereditary spastic paraplegias (HSPs) are a group of rare inherited neurological diseases
characterized by extreme heterogeneity in both their clinical manifestations and genetic …

Background Although many causative genes of hereditary spastic paraplegia (HSP) have
been uncovered in recent years, there are still approximately 50% of HSP patients without …