Decreased metabolic flexibility, ie a compromised ability to adjust fuel oxidation to fuel
availability supports development of adverse consequences of obesity. The aims of this …

We compared, across several physiological variables, rats most and least susceptible to
develop obesity when given a high-fat diet. After 4 wk of eating a high-fat diet (60% of …

Indices of both carbohydrate and lipid metabolism were examined in obese (C57BL/6J
ob/ob) mice and lean controls at 4-5 months of age in both the fed and fasted condition …

In association with moderate diabetes, fully mature obese mice (C57BL 6J ob ob) display
several disturbances of metabolism, behavior, and growth. As yet, no precise developmental …

Background strain is known to influence the way a genetic manipulation affects mouse
phenotypes. Despite data that demonstrate variations in the primary phenotype of basic …

We have previously shown that C57BL/6J (B6) mice develop severe obesity and diabetes if
weaned onto high-fat diets, whereas A/J mice tend to be obesity and diabetes-resistant. The …

C57BL/6J mice were fed a high-fat, carbohydrate-free diet (HFD) for 9 mo. Approximately
50% of the mice became obese and diabetic (ObD),∼ 10% lean and diabetic (LD),∼ 10 …

This study aimed to compare energy balance, metabolic profiles and body composition
between two inbred strains of rats (F344 and Lou) submitted to a self-selecting …

Background Achieving weight loss is the cornerstone of the treatment of the metabolic
consequences of obesity, in particular of glucose intolerance. Objective To determine …

Although it is now becoming more evident that the strain of mouse used to generate
genetically modified models for the study of endocrine disorders contributes to the ensuing …