Objective: To characterize the phenotypic consequences of long‐term selective breeding for
rapid weight gain, with an emphasis on obesity and obesity‐induced diabetes (diabesity) …

Among outbred Sprague-Dawley rats, approximately one-half develop diet-induced obesity
(DIO) and one-half are diet resistant (DR) on a diet relatively high in fat and energy content …

Objective: The metabolic syndrome refers to a constellation of signs including abdominal
obesity, elevated serum triglycerides, low HDL‐cholesterol, elevated blood pressure, and …

A large number of animal models are currently used in appetite and obesity research.
Because the worldwide incidence of obesity continues to climb, it is imperative that animal …

Metabolically intact NMRI mice and genetically obese NZO mice were fed ad lib. either a
high-carbohydrate diet (standard) or a high-fat diet for a period of about 11 (NMRI mice) or …

Half of Sprague-Dawley rats develop and defend diet-induced obesity (DIO) or diet
resistance (DR) when fed a high-energy (HE) diet. Here, adult male rats were made DIO or …

The recently developed Otsuka Long-Evans Tokushima Fatty (OLETF) rat is known to
develop insulinopenic diabetes after a prolonged period in a condition resembling non …

Rates of glucose turnover and of glucose-carbon recycling in fed and fasted C57B1/6 ob/ob
mice were measured using D-[6 (-3) H/U-14C]-glucose. In both the fed and fasted state …

The sensitivity to insulin was studied both in vivo and in vitro on obese-hyperglycemic mice
having free access to food (obob ad lib), on obese whose body weight had returned to …

Caloric restriction (CR) extends healthy lifespan in many organisms. DBA/2 mice, unlike
C57BL/6 mice, are reported to be unresponsive to CR. To investigate potential differences …