Alternate‐day fasting (ADF) causes body weight (BW) loss in humans and rodents.
However, it is not clear that ADF while maintaining a high‐fat (HF) diet results in weight loss …

High–fat (HF) diet-induced obesity and insulin insensitivity are associated with inflammation,
particularly in white adipose tissue (WAT). However, insulin insensitivity is apparent within …

Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability.
The inability to modify fuel oxidation in response to changes in nutrient availability has been …

Aims/hypothesis Recent work has shown that there can be significant differences when
glucose disposal is assessed for high-fat induced insulin resistance by static clamp methods …

In nature, animals must successfully respond to many simultaneous demands from their
environment in order to survive and reproduce. We examined physiological and …

The mass of food hoarded by rats given access to food only 2 h per day is proportional to the
rats' body weight deficit. The intersect of the regression line of hoarded food plotted against …

Previous research in our laboratory has demonstrated that the C57BL/6J (B/6J) mouse has a
predisposition to develop severe obesity if placed on a high-fat diet. In the present study we …

Food restriction paradigms are widely used in animal studies to investigate systems involved
in energy regulation. We have observed behavioral, physiological, and molecular …

The C57BL/6 mouse strain fed a high‐fat diet (HFD) with~ 60% of kcals from fat (lard) is an
established rodent model of diet‐induced obesity. To determine if there is an ideal start age …

Challenge tests stress homeostasis and may reveal deviations in health that remain masked
under unchallenged conditions. Ideally, challenge tests are non-invasive and applicable in …