BACKGROUND: Vascular smooth muscle cells (VSMCs) are highly plastic. Vessel injury
induces a phenotypic transformation from differentiated to dedifferentiated VSMCs, which …

Background: Endothelial-to-mesenchymal transition (EndMT) has been identified as a
critical driver of vascular inflammation and atherosclerosis, and TGF-β (transforming growth …

During heart development, TN-C is transiently expressed at restricted sites at several
important steps of heart morphogenesis: 27 (1) differentiation of cardiomyocytes,(2) cushion …

Tenascins are a family of large extracellular matrix (ECM) glycoproteins. Four family
members (tenascin-C,-R,-X, and-W) have been identified to date. Each member consists of …

Tenascin‐C (TNC) is an extracellular glycoprotein categorized as a matricellular protein. It is
highly expressed during embryonic development, wound healing, inflammation, and cancer …

An extracellular matrix tenascin‐X (TNX) is highly expressed in muscular tissues, especially
heart and skeletal muscle, and is also prominent around blood vessels. The precise in vivo …

Tenascin-C (TN-C) is induced in pulmonary vascular disease, where it colocalizes with
proliferating smooth muscle cells (SMCs) and epidermal growth factor (EGF). Furthermore …

The extracellular matrix protein tenascin C (TnC) is expressed in a variety of embryonic
tissues, but its expression in adult arteries is co-incident with sites of vascular disease. TnC …

Living tissue is composed of cells and extracellular matrix (ECM). In the heart and blood
vessels, which are constantly subjected to mechanical stress, ECM molecules form well …

Objective—Based on our previous observations on the expression of Tenascin-C (Tn-C) in
human atherosclerotic plaques and its colocalization with macrophages, we explored …