It is desirable for a pharmaceutical final dosage form to be manufactured through a quality
by design (QbD)-based approach rather than a quality by testing (QbT) approach. An …

The next generation of QbD based pharmaceutical products will be manufactured through
continuous processing. This will allow the integration of online/inline monitoring tools …

Continuous pharmaceutical manufacturing together with PAT (Process Analytical
Technology) provides a suitable platform for automatic control of the end product quality as …

In the context of continuous pharmaceutical oral dosage manufacturing, a control system is
essential to ensure that the critical quality attributes (CQAs) are maintained within the …

In continuous pharmaceutical manufacturing, real-time precise control of critical quality
attributes (CQAs) is necessary for quality by design (QbD)-based manufacturing and real …

A novel manufacturing strategy based on continuous processing integrated with
online/inline monitoring tools coupled with an advanced control system is highly desired for …

The pharmaceutical industry is strictly regulated, where precise and accurate control of the
end product quality is necessary to ensure the effectiveness of the drug products. For such …

A novel manufacturing strategy based on continuous processing integrated with online
monitoring tools coupled with efficient automatic feedback control system is highly desired …

Abstract The Quality-by-Design (QbD) guidance issued by the US Food and Drug
Administration (FDA) has catalyzed the modernization of pharmaceutical manufacturing …

In this manuscript, a moving horizon-based real-time optimization (MH-RTO) has been
integrated with a hybrid model predictive control (MPC) system for a continuous tablet …