Background & Aims A genome-wide association study (GWAS) of 280 cases identified the
hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease …

Gallstone disease is a common complex disease that confers a substantial economic
burden on society. The genetic underpinnings of gallstone disease remain incompletely …

Abstract Background and Aims Genome‐wide association studies (GWAS) have identified
several risk loci for gallstone disease. As with most polygenic traits, it is likely that many …

With an overall prevalence of 10–20%, gallstone disease (cholelithiasis) represents one of
the most frequent and economically relevant health problems of industrialized countries,. We …

Gallstones are responsible for one of the most common diseases in the Western world and
are commonly treated with cholecystectomy. We perform a meta-analysis of two genome …

Background Gallstones are abnormal masses caused by impaired metabolism of
cholesterol, bilirubin, or bile salts in the gallbladder or biliary tract. ATP-binding cassette …

BACKGROUND & AIMS: Genome-wide association studies have mapped loci that are
associated with serum levels of bilirubin. Bilirubin is a major component of gallstones so we …

Background & Aims Obesity, type 2 diabetes, and lifestyle factors (cigarette smoking, alcohol
drinking, and coffee consumption) have been associated with the risk of developing …

Background & Aims Adiposity has been consistently associated with gallstone disease risk.
We aimed to characterize associations of anthropometric measures (body mass index [BMI] …

Gallbladder disease (GBD) is one of the major digestive diseases. Its risk factors include
age, sex, obesity, type 2 diabetes, and metabolic syndrome (MS). The prevalence of GBD is …