Objectives: The study sought to test the hypothesis that genetic variation in ABCG5/8, the
transporter responsible for intestinal and hepatobiliary cholesterol efflux, may …

Background & Aims: Cholesterol gallstone formation is a complex genetic trait. To identify
additional cholesterol gallstone susceptibility loci, we performed a quantitative trait locus …

Background Gallbladder disease (GBD) is a highly prevalent condition; however, little is
known about potential differences in risk factors by sex and ethnicity/race. Our aim was to …

Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial
burden to health care systems that is expected to increase in ageing populations at risk. This …

Backgrounds & Aims Primary biliary cholangitis (PBC) is a chronic liver disease in which
autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis …

Aims Myocardial infarction (MI) and gallstone disease (GSD) are intrinsically linked via
cholesterol metabolism. We tested the hypothesis that genetic variants in the gene encoding …

Most epidemiological surveys have confirmed the association of low HDL-cholesterol and
high triglyceride levels with cholesterol gallstones. Our objective was to analyze the …

Gallstones are common in Western countries and due to pain and complications pose a
substantial burden on health care systems. In general, cholesterol gallstones are …

Cholesterol 7-α hydroxylase (CYP7A1), which is a rate-limiting enzyme for cholesterol
catabolism and bile acid synthesis, may affect cholesterol homeostasis and result in …

Gallbladder carcinoma (GBC) usually arises in the background of gallstone disease.
Cholesterol 7α-hydroxylase (CYP7A1) is a rate-limiting enzyme for cholesterol catabolism …