Gallstones are common in Western countries and due to pain and complications pose a
substantial burden on health care systems. In general, cholesterol gallstones are …

Cholesterol 7-α hydroxylase (CYP7A1), which is a rate-limiting enzyme for cholesterol
catabolism and bile acid synthesis, may affect cholesterol homeostasis and result in …

Gallbladder carcinoma (GBC) usually arises in the background of gallstone disease.
Cholesterol 7α-hydroxylase (CYP7A1) is a rate-limiting enzyme for cholesterol catabolism …

Abstract Background and Aims The risk factors of cholelithiasis have not been clearly
identified, especially for total cholesterol. Here, we try to identify these causal risk factors …

Biliary atresia (BA) is characterized by the progressive fibrosclerosing obliteration of the
extrahepatic biliary system during the first few weeks of life. Despite early diagnosis and …

The liver is currently known to be the major organ to eliminate excess cholesterol from our
body. It accomplishes this function in two ways: conversion of cholesterol molecules into bile …

Cholesterol cholelithiasis is one of the most prevalent digestive diseases, resulting in a
considerable financial and social burden worldwide. In the United States, at least 20 million …

BACKGROUND & AIMS: We aimed to characterize the genetic susceptibility to primary
sclerosing cholangitis (PSC) by means of a genome-wide association analysis of single …

Objective To explore the prevalence of and risk factors for gallstone disease in Shanghai,
China. Methods A population‐based cross‐sectional study was conducted in Shanghai …

Background Cholelithiasis is a multifactorial process and several mechanisms of gallstone
formation have been postulated. As one of these mechanisms, a decreased expression of …