Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels
Two new P2X receptor cDNAs (P2X5 and P2X6) were isolated and expressed. All six
proteins are 36–48 percent identical and seem to have two transmembrane segments with a …
proteins are 36–48 percent identical and seem to have two transmembrane segments with a …
Cloning and tissue distribution of a novel P2X receptor from rat brain
F Soto, M Garcia-Guzman, C Karschin… - … and biophysical research …, 1996 - Elsevier
We have isolated the cDNA for a novel member (P2X6) of the ATP-gated ion channel family.
The rat P2X6nucleotide sequence encodes a 379 amino acid protein that conserves all the …
The rat P2X6nucleotide sequence encodes a 379 amino acid protein that conserves all the …
Domains of P2X receptors involved in desensitization
P Werner, EP Seward, GN Buell… - Proceedings of the …, 1996 - National Acad Sciences
ATP-gated ion channels (P2X receptors) are abundantly expressed in both neuronal and
nonneuronal tissues, where they can serve as postsynaptic receptors. The response to ATP …
nonneuronal tissues, where they can serve as postsynaptic receptors. The response to ATP …
Functional and Biochemical Evidence for Heteromeric ATP-gated Channels Composed of P2X1 and P2X5Subunits
KT Lê, E Boué-Grabot, V Archambault… - Journal of Biological …, 1999 - ASBMB
The mammalian P2X receptor gene family encodes two-transmembrane domain
nonselective cation channels gated by extracellular ATP. Anatomical localization data …
nonselective cation channels gated by extracellular ATP. Anatomical localization data …
An antagonist‐insensitive P2X receptor expressed in epithelia and brain.
A cDNA was cloned which encodes a new ATP‐gated ion channel (P2X4 receptor). ATP
induces a cationic current in HEK293 cells transfected with the P2X4 receptor. However, the …
induces a cationic current in HEK293 cells transfected with the P2X4 receptor. However, the …
Molecular physiology of P2X receptors
RA North - Physiological reviews, 2002 - journals.physiology.org
P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …
[HTML][HTML] Desensitization of the P2X2 receptor controlled by alternative splicing
U Brändle, P Spielmanns, R Osteroth, J Sim… - FEBS letters, 1997 - Elsevier
P2X receptors are ion channels gated by extracellular ATP. We report here cloning of a
P2X2 receptor splice variant (P2X2-2) carrying a 207 bp deletion in the intracellular C …
P2X2 receptor splice variant (P2X2-2) carrying a 207 bp deletion in the intracellular C …
Distribution of the P2X2 receptor subunit of the ATP‐gated ion channels in the rat central nervous system
R Kanjhan, GD Housley, LD Burton… - Journal of …, 1999 - Wiley Online Library
The distribution of the P2X2 receptor subunit of the adenosine 5′‐triphosphate (ATP)‐
gated ion channels was examined in the adult rat central nervous system (CNS) by using …
gated ion channels was examined in the adult rat central nervous system (CNS) by using …
Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia
Z Xiang, X Bo, G Burnstock - Neuroscience letters, 1998 - Elsevier
The distribution of P2X1, P2X2, P2X3, P2X4, P2X5 and P2X6 receptors, a family of ATP-
gated cation channels, in rat trigeminal, dorsal root, nodose, superior cervical, and coeliac …
gated cation channels, in rat trigeminal, dorsal root, nodose, superior cervical, and coeliac …
Baculovirus expression provides direct evidence for heteromeric assembly of P2X2 and P2X3 receptors
KM Radford, C Virginio, A Surprenant… - Journal of …, 1997 - Soc Neuroscience
P2X2 and P2X3 are subunits of P2X receptors, cation channels opened by binding
extracellular ATP. cDNAs encoding P2X2 and P2X3 receptor subunits, each with one of two …
extracellular ATP. cDNAs encoding P2X2 and P2X3 receptor subunits, each with one of two …