[HTML][HTML] Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis

P Vempati, AS Popel… - BMC systems …, 2011 - bmcsystbiol.biomedcentral.com
The spatial distribution of vascular endothelial growth factor A (VEGF) is an important
mediator of vascular patterning. Previous experimental studies in the mouse hindbrain and …

[HTML][HTML] Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies

SD Finley, MO Engel-Stefanini, PI Imoukhuede… - BMC systems …, 2011 - Springer
Background Vascular endothelial growth factor (VEGF) is a potent regulator of
angiogenesis, and its role in cancer biology has been widely studied. Many cancer …

Comparative structure‐function analysis of VEGFR‐1 and VEGFR‐2: What have we learned from chimeric systems?

RD Meyer, N Rahimi - Annals of the New York Academy of …, 2003 - Wiley Online Library
Activation of vascular endothelial growth factor receptor‐1 and‐2 (VEGFR‐1 and VEGFR‐2)
plays a critical role in vasculogenesis and angiogenesis. However, the mechanism by which …

Localization of vascular response to VEGF is not dependent on heparin binding

ML Springer, A Banfi, J Ye, G von Degenfeld… - The FASEB …, 2007 - Wiley Online Library
The major vascular endothelial growth factor (VEGF) isoforms are splice variants from a
single gene that differ in their extent of heparin affinity due to the absence of the heparin …

Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia

PI Imoukhuede, AO Dokun… - American Journal of …, 2013 - journals.physiology.org
VEGF receptor (VEGFR) cell surface localization plays a critical role in transducing VEGF
signaling toward angiogenic outcomes, and quantitative characterization of these …

[HTML][HTML] Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns

M Jeltsch, T Karpanen, T Strandin, K Aho… - Journal of Biological …, 2006 - ASBMB
Vascular endothelial growth factors (VEGFs) and their receptors play key roles in
angiogenesis and lymphangiogenesis. VEGF activates VEGF receptor-1 (VEGFR-1) and …

[HTML][HTML] Dimerization of VEGF receptors and implications for signal transduction: a computational study

F Mac Gabhann, AS Popel - Biophysical chemistry, 2007 - ncbi.nlm.nih.gov
Vascular endothelial growth factor (VEGF) is a potent cytokine involved in the induction of
neovascularization. Secreted as a cysteine-linked dimer, it has two binding sites at opposite …

Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms

SD Finley, AS Popel - The AAPS journal, 2012 - Springer
Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, whose effect
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …

[HTML][HTML] VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy

N Rahimi - Frontiers in bioscience: a journal and virtual library, 2006 - ncbi.nlm.nih.gov
Angiogenesis involves endothelial cell differentiation, proliferation, migration and cord
formation, which lead to tubulogenesis to form vessels. One group of growth factor receptors …

VEGF receptor protein–tyrosine kinases: structure and regulation

R Roskoski Jr - Biochemical and biophysical research communications, 2008 - Elsevier
The human VEGF family consists of VEGF (VEGF-A), VEGF-B, VEGF-C, VEGF-D, and
placental growth factor (PlGF). The VEGF family of receptors consists of three protein …