Chromatin posttranslational modifications (PTMs), including monoubiquitylation of histone
H2B on lysine 120 (H2Bub1), play a major role in regulating genome functions. To elucidate …

Histone H2A. Bbd (Barr body-deficient) is a novel histone variant which is largely excluded
from the inactive X chromosome of mammals. Discovered only 6 years ago, H2A. Bbd …

Dear Editor, p53-binding protein 1 (53BP1) is a critical regulator of cellular response to DNA
double-strand breaks (DSBs)[1]. To accomplish its repair function, 53BP1 must be recruited …

Mono-ubiquitylation of histone H2B correlates with transcriptional activation and is required
for di-and trimethylation at Lys 4 on the histone H3 tail (H3K4) by the SET1/COMPASS …

Monoubiquitinated histone H2B plays multiple roles in transcription activation. H2B is
deubiquitinated by the Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator, which contains a …

Although the BBAP E3 ligase and its binding partner BAL are overexpressed in
chemotherapy-resistant lymphomas, the role of these proteins in DNA damage responses …

The regulation of chromatin structure is essential to life. In eukaryotic organisms, several
classes of protein exist that can modify chromatin structure either through ATP-dependent …

Post-translational modification of histones plays an integral role in regulation of genomic
expression through modulation of chromatin structure and function. Chemical preparations …

Monoubiquitination of histone H2B is required for methylation of histone H3 on lysine 4 (K4),
a modification associated with active chromatin. The identity of the cognate ubiquitin ligase …

Histone post-translational modification is a key step that may result in an epigenetic mark
that regulates chromatin structure and gene transcriptional activity thereby impacting many …