Paramutation is a heritable epigenetic modification induced in plants by cross-talk between
allelic loci. Here we report a similar modification of the mouse Kit gene in the progeny of …

THE origin of the RNA world1 is not easily understood, as effective prebiotic syntheses of the
components of RNA, the β-ribofurano-side-5′-phosphates, are hard to envisage2 …

The organization and large size of the mammalian cell genome allows spatial separation of
different transcription units. In those cases where more than one species of messenger are …

Abstract Small (< 200 nucleotide) RNA (sRNA) profiling of human cells using various
technologies demonstrates unexpected complexity of sRNAs with hundreds of thousands of …

We have searched the human genome for genes encoding new proteins that may be
involved in three nuclear gene expression processes: transcription, pre-messenger RNA …

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In the ciliate Paramecium, transposable elements and their single-copy remnants are
deleted during the development of somatic macronuclei from germline micronuclei, at each …

[illus. 1] Some call them DNA chips, others microarrays, but whatever name you prefer, they
are one of the hottest tools in biology. A search of the Medline database for papers …

Eukaryotic cells make many types of primary and processed RNAs that are found either in
specific subcellular compartments or throughout the cells. A complete catalogue of these …

A KEY question concerning the mechanism of transcriptional activation by enhancers is
about the role of the DNA that connects the enhancer to the promoter1–3. The linking DNA …