Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain
The relationship between genetic variation and gene expression in brain cell types and
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases
Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …
variants associated with disease phenotypes. However, most of these variants do not alter …
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
MAA DeMichele-Sweet, L Klei, B Creese… - Molecular …, 2021 - nature.com
Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent
in Alzheimer disease (AD with psychosis, AD+ P). AD+ P affects~ 50% of individuals with …
in Alzheimer disease (AD with psychosis, AD+ P). AD+ P affects~ 50% of individuals with …
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium
Late-onset Alzheimer disease (AD) has a complex genetic etiology, involving locus
heterogeneity, polygenic inheritance, and gene-gene interactions; however, the …
heterogeneity, polygenic inheritance, and gene-gene interactions; however, the …
The complex genetic architecture of Alzheimer's disease: novel insights and future directions
SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …
disorder and the most common form of dementia. AD is highly heritable, with heritability …
Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease
JC Lambert, A Ramirez, B Grenier-Boley… - Molecular …, 2023 - nature.com
Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …
of this component has progressed over the last 10 years, thanks notably to the advent of …
Genome-wide association studies for Alzheimer's disease: bigger is not always better
V Escott-Price, J Hardy - Brain Communications, 2022 - academic.oup.com
As the size of genome-wide association studies increase, the number of associated trait loci
identified inevitably increase. One welcomes this if it allows the better delineation of the …
identified inevitably increase. One welcomes this if it allows the better delineation of the …
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities
Background Alzheimer's disease (AD) is the most common cause of dementia in the elderly
and the sixth leading cause of death in the United States. AD is mainly considered a …
and the sixth leading cause of death in the United States. AD is mainly considered a …