Physiological hypoxia results in a host of responses that include increased ventilation,
constriction of the pulmonary artery, and a cellular transcriptional program that promotes …

All eukaryotic cells utilize oxidative phosphorylation to maintain their high‐energy
phosphate stores. Mitochondrial oxygen consumption is required for ATP generation, and …

Mitochondria are responsible for the majority of oxygen consumption in cells, and thus
represent a conceptually appealing site for cellular oxygen sensing. Over the past 40 years …

Mitochondria are proposed to play an important role in hypoxic cell signaling. One currently
accepted signaling paradigm is that the mitochondrial generation of reactive oxygen species …

Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell
proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF) …

Decreased oxygen availability (hypoxia) promotes physiological processes such as energy
metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor …

There are numerous mechanisms by which mammals respond to hypoxia. These include
acute changes in pulmonary arterial tone due to smooth muscle cell contraction, acute …

Mammalian cells have divergent responses to varying oxygen levels. Cells exposed to low
oxygen levels (hypoxia) activate the transcription factor hypoxia-inducible factor-1 (HIF-1) as …

Generation, transformation, and utilization of organic molecules in support of cellular
differentiation, growth, and maintenance are basic tenets that define life. In eukaryotes …

The molecular oxygen (O2) paradox was coined to describe its essential nature and toxicity.
The latter characteristic of O2 is associated with the formation of reactive oxygen species …