Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease

I Ahmed, R Greenwood, B Costello… - Alimentary …, 2016 - Wiley Online Library
Background The aetiology of inflammatory bowel disease (IBD) remains poorly understood.
Recent evidence suggests an important role of gut microbial dysbiosis in IBD, and this may …

An investigation of fecal volatile organic metabolites in irritable bowel syndrome

I Ahmed, R Greenwood, BL Costello, NM Ratcliffe… - PloS one, 2013 - journals.plos.org
Diagnosing irritable bowel syndrome (IBS) can be a challenge; many clinicians resort to
invasive investigations in order to rule out other diseases and reassure their patients …

Volatomics in inflammatory bowel disease and irritable bowel syndrome

K Van Malderen, BY De Winter, G Joris… - …, 2020 - thelancet.com
Volatile organic compounds (VOCs) are produced by the human metabolism, inflammation
and gut microbiota and form the basis of innovative volatomics research. VOCs detected …

Volatile organic compounds in exhaled air as novel marker for disease activity in Crohn's disease: a metabolomic approach

AGL Bodelier, A Smolinska, A Baranska… - Inflammatory bowel …, 2015 - academic.oup.com
Background Disappearance of macroscopic mucosal inflammation predicts long-term
outcome in Crohn's disease (CD). It can be assessed by ileocolonoscopy, which is …

Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD

V De Preter, K Machiels, M Joossens, I Arijs, C Matthys… - Gut, 2015 - gut.bmj.com
Background Bacteria play a role in the onset and perpetuation of intestinal inflammation in
IBD. Compositional alterations may also change the metabolic capacities of the gut bacteria …

Analysis of exhaled breath volatile organic compounds in inflammatory bowel disease: a pilot study

LC Hicks, J Huang, S Kumar, ST Powles… - Journal of Crohn's …, 2015 - academic.oup.com
Abstract Background and Aims: Distinguishing between the inflammatory bowel diseases
[IBD], Crohn's disease [CD] and ulcerative colitis [UC], is important for determining …

[HTML][HTML] Non-invasive exhaled volatile organic biomarker analysis to detect inflammatory bowel disease (IBD)

RP Arasaradnam, M McFarlane, E Daulton… - Digestive and Liver …, 2016 - Elsevier
Introduction Early inflammatory bowel disease (IBD) diagnosis remains a clinical challenge.
Volatile organic compounds (VOCs) have shown distinct patterns in Crohn's disease (CD) …

The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis

A Smolinska, AGL Bodelier, JW Dallinga… - Alimentary …, 2017 - Wiley Online Library
Background To optimise treatment of ulcerative colitis (UC), patients need repeated
assessment of mucosal inflammation. Current non‐invasive biomarkers and clinical activity …

Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals

JT Bjerrum, Y Wang, F Hao, M Coskun, C Ludwig… - Metabolomics, 2015 - Springer
This study employs spectroscopy-based metabolic profiling of fecal extracts from healthy
subjects and patients with active or inactive ulcerative colitis (UC) and Crohn's disease (CD) …

Serum and urine metabolomic profiling of newly diagnosed treatment-naïve inflammatory bowel disease patients

L Aldars-García, R Gil-Redondo… - Inflammatory Bowel …, 2024 - academic.oup.com
Abstract Background and Aims Inflammatory bowel disease (IBD) is a prevalent chronic
noncurable disease associated with profound metabolic changes. The discovery of novel …