Issues in comparisons between meta-analyses and large trials
Context.—The extent of concordance between meta-analyses and large trials on the same
topic has been investigated with different protocols. Inconsistent conclusions created …
topic has been investigated with different protocols. Inconsistent conclusions created …
Discrepancies between meta-analyses and subsequent large randomized, controlled trials
J LeLorier, G Gregoire, A Benhaddad… - … England Journal of …, 1997 - Mass Medical Soc
Background Meta-analyses are now widely used to provide evidence to support clinical
strategies. However, large randomized, controlled trials are considered the gold standard in …
strategies. However, large randomized, controlled trials are considered the gold standard in …
The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials
When little or no data directly comparing two treatments are available, investigators often
rely on indirect comparisons from studies testing the treatments against a control or placebo …
rely on indirect comparisons from studies testing the treatments against a control or placebo …
Strengths and limitations of meta-analysis: larger studies may be more reliable
Meta-analysis of randomized controlled trials combines information from independent
studies that address a similar question to provide more reliable estimates of treatment …
studies that address a similar question to provide more reliable estimates of treatment …
Meta-analysis of randomized controlled trials: a concern for standards
D Moher, I Olkin - Jama, 1995 - jamanetwork.com
Evidence-based health care is becoming increasingly popular and, at least in some settings,
is being used to assist in the creation of health care policy. 1 Meta-analyses are a key …
is being used to assist in the creation of health care policy. 1 Meta-analyses are a key …
Meta-analysis: methods, strengths, weaknesses, and political uses
JH Noble Jr - Journal of Laboratory and Clinical Medicine, 2006 - Elsevier
The general methodology, strengths and weaknesses, and political uses of meta-analysis
are examined. As a systematic study of all studies that have been conducted to answer a …
are examined. As a systematic study of all studies that have been conducted to answer a …
Statistically significant meta-analyses of clinical trials have modest credibility and inflated effects
TV Pereira, JPA Ioannidis - Journal of clinical epidemiology, 2011 - Elsevier
OBJECTIVE: To assess whether nominally statistically significant effects in meta-analyses of
clinical trials are true and whether their magnitude is inflated. STUDY DESIGN AND …
clinical trials are true and whether their magnitude is inflated. STUDY DESIGN AND …
Meta-analysis: science or religion?
CL Meinert - Controlled clinical trials, 1989 - Elsevier
Meta-analysis of clinical trials has assumed increasing importance in recent years as a
means of reaching conclusions regarding the safety and efficacy of treatments evaluated in …
means of reaching conclusions regarding the safety and efficacy of treatments evaluated in …
Where now for meta-analysis?
Figure 1 Distinguished statistician Karl Pearson is seen as the first medical researcher to
use formal techniques to combine data from different studies studies are needed. For …
use formal techniques to combine data from different studies studies are needed. For …
Meta-analysis as evidence: building a better pyramid
JA Berlin, RM Golub - Jama, 2014 - jamanetwork.com
In following the practice of evidence-based medicine, when faced with a question about
prevention or treatment the clinician should seek out the best evidence that addresses the …
prevention or treatment the clinician should seek out the best evidence that addresses the …