In eukaryotes, the nuclear membrane provides a physical barrier to the passive diffusion of
macromolecules from and into the cytoplasm. Nucleocytoplasmic traffic occurs through …

A striking property of nuclear pore complexes is their ability to mediate bi-directional
nucleocytoplasmic traffic of proteins and RNAs. In the past year, several new nuclear pore …

SUMMARY A defining characteristic of eukaryotic cells is the possession of a nuclear
envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments …

In eukaryotic cells, cell functions are maintained in an orderly manner through the
continuous traffic of various proteins between the cell nucleus and the cytoplasm. The …

Molecules enter and exit the nucleus of eukaryotic cells through aqueous channels formed
in the nuclear envelope by nuclear pore complexes (NPC). Proteins entering or leaving the …

The nuclear import of proteins through nuclear pore complexes (NPCs) illustrates how a
complex biological function can be generated by a spatially and temporally organized cycle …

Transport of proteins into and out of the nucleus occurs through nuclear pore complexes
(NPC). A heterodimeric protein complex, composed of karyopherin a and β (or importin α …

Macromolecules enter or leave the nucleus by using nuclear localization signals (NLS), or
nuclear export signals (NES), respectively. Different types of NLS and NES are recognized …

The trafficking of protein and RNA cargoes between the cytoplasm and the nucleus of
eukaryotic cells, which is a major pathway involved in cell regulation, is mediated by nuclear …

Transport of proteins, RNAs and ribonucleoprotein particles into and out of the nucleus is
essential for many cellular functions to proceed. Recent progress in this area of research …