Air pollution–mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice

C Liu, X Xu, Y Bai, TY Wang, X Rao… - Environmental …, 2014 - ehp.niehs.nih.gov
Background: Epidemiologic and experimental studies support an association between PM2.
5 exposure and insulin resistance (IR). Innate immune cell activation has been suggested to …

Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity

Q Sun, P Yue, JA Deiuliis, CN Lumeng, T Kampfrath… - Circulation, 2009 - Am Heart Assoc
Background—There is a strong link between urbanization and type 2 diabetes mellitus.
Although a multitude of mechanisms have been proposed, there are no studies evaluating …

Epidemiological and experimental links between air pollution and type 2 diabetes

C Liu, Z Ying, J Harkema, Q Sun… - Toxicologic …, 2013 - journals.sagepub.com
There is increasing evidence suggesting links between exposure to environmental toxins
and susceptibility to type 2 diabetes mellitus (DM). In this review, we summarize the …

Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue

X Xu, C Liu, Z Xu, K Tzan, M Zhong… - Toxicological …, 2011 - academic.oup.com
We have previously shown that chronic exposure to ambient fine particulate matter (less
than 2.5 μm in aerodynamic diameter, PM2. 5) pollution in conjunction with high-fat diet …

Airborne PM2.5-Induced Hepatic Insulin Resistance by Nrf2/JNK-Mediated Signaling Pathway

J Xu, W Zhang, Z Lu, F Zhang, W Ding - International journal of …, 2017 - mdpi.com
Animal and epidemiological studies have suggested that exposure to airborne particulate
matter (PM) with an aerodynamic diameter less than 2.5 μm (PM2. 5) is associated with the …

Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model

Z Zheng, X Xu, X Zhang, A Wang, C Zhang… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Air pollution is a global challenge to public health. Epidemiological
studies have linked exposure to ambient particulate matter with aerodynamic diameters< 2.5 …

Exposure to fine particulate air pollution causes vascular insulin resistance by inducing pulmonary oxidative stress

P Haberzettl, TE O'Toole, A Bhatnagar… - Environmental health …, 2016 - ehp.niehs.nih.gov
Background: Epidemiological evidence suggests that exposure to ambient air fine
particulate matter (PM2. 5) increases the risk of developing type 2 diabetes and …

Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice

R Li, Q Sun, SM Lam, R Chen, J Zhu, W Gu… - Particle and fibre …, 2020 - Springer
Background & aims Emerging evidence supports ambient fine particulate matter (PM 2.5)
exposure is associated with insulin resistance (IR) and hepatic lipid accumulation. In this …

Inflammatory response to fine particulate air pollution exposure: neutrophil versus monocyte

X Xu, SY Jiang, TY Wang, Y Bai, M Zhong, A Wang… - PLoS …, 2013 - journals.plos.org
Objectives Studies have shown that chronic exposure to ambient fine particulate matter (less
than 2.5 µ m in aerodynamic diameter, PM2. 5) pollution induces insulin resistance through …

Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus

C Liu, Y Bai, X Xu, L Sun, A Wang, TY Wang… - Particle and fibre …, 2014 - Springer
Background Prior experimental and epidemiologic data support a link between exposure to
fine ambient particulate matter (< 2.5 μm in aerodynamic diameter, PM 2.5) and …