Hemostasis factors and aging

D Mari, R Coppola, R Provenzano - Experimental gerontology, 2008 - Elsevier
With advancing age, an increasing number of healthy individuals have laboratory signs of
heightened coagulation enzyme activity. Such biochemical hypercoagulability might be the …

Hypercoagulability in centenarians: the paradox of successful aging

D Mari, PM Mannucci, R Coppola, B Bottasso… - 1995 - ashpublications.org
With advancing age, an increasing number of healthy individuals have laboratory signs of
heightened coagulation enzyme activity. Such biochemical hypercoagulability might be the …

Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins: a study in centenarians

PM Mannucci, D Mari, G Merati… - … , and vascular biology, 1997 - Am Heart Assoc
Gene polymorphisms associated with the plasma levels of fibrinogen, factor VII, and
plasminogen activator inhibitor 1 (PAI-1)—hemostasis proteins that help to predict the risk of …

Hemostasis and ageing

D Mari, G Ogliari, D Castaldi, G Vitale, EM Bollini… - Immunity & …, 2008 - Springer
Abstract On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related
Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is …

[HTML][HTML] Genetic influence on thrombotic risk markers in the elderly–a Danish twin study

EM Bladbjerg, MPM De Maat, K Christensen… - Journal of Thrombosis …, 2006 - Elsevier
Objective: Several hemostatic variables are identified as cardiovascular risk markers. In
young and middle‐aged individuals, plasma concentrations of these variables are partly …

Aging hemostasis: changes to laboratory markers of hemostasis as we age—a narrative review

EJ Favaloro, M Franchini, G Lippi - Seminars in thrombosis and …, 2014 - thieme-connect.com
The incidence of venous thromboembolism (VTE) is well recognized to increase with aging.
Concurrently, the plasma concentrations of many coagulation factors (eg, fibrinogen, factor …

Aging and thrombosis

WR Wilkerson, DC Sane - Seminars in thrombosis and …, 2002 - thieme-connect.com
Advanced age is associated with a dramatic increase in the rates of venous and arterial
thrombotic events. Increases in fibrinogen, factors VIII and IX, and other coagulation …

Longevity is independent of common variations in genes associated with cardiovascular risk

EM Bladbjerg, K Andersen-Ranberg… - Thrombosis and …, 1999 - thieme-connect.com
Do extremely old persons have a genetically favourable profile which has protected them
from cardiovascular death? We have tried to answer this question by measuring DNA …

Blood coagulation factors in the elderly

K Hager, J Setzer, T Vogl, J Voit, D Platt - Archives of gerontology and …, 1989 - Elsevier
To investigate causes of the age-dependent increase of thromboembolic events, plasma
coagulation parameters were determined in healthy elderly blood donors in comparison with …

Relation of the prothrombotic state to increasing age (from the Framingham Offspring Study)

GH Tofler, J Massaro, D Levy, M Mittleman… - The American journal of …, 2005 - Elsevier
A greater life expectancy has led to an increasing proportion of elderly patients. Increasing
age is an important risk factor for cardiovascular disease, but the mechanism of risk is not …