Temporomandibular joint disorder is a common chronic craniofacial pain condition, often
involving persistent, widespread craniofacial muscle pain. Although the etiology of chronic …

Craniofacial muscle pain is highly prevalent in temporomandibular disorders but is difficult to
treat. Enhanced understanding of neurobiology unique to craniofacial muscle pain should …

Craniofacial muscle pain, such as spontaneous pain and bite-evoked pain, are major
symptoms in patients with temporomandibular disorders and infection. However, the …

The purpose of the present review is to correlate recent knowledge of the role of peripheral
ionotropic glutamate receptors in the temporomandibular joint and muscle pain from animal …

Spontaneous pain and function-associated pain are prevalent symptoms of multiple acute
and chronic muscle pathologies. We established mouse models for evaluating spontaneous …

Musculoskeletal pain conditions, particularly those associated with temporomandibular
disorders (TMD) affect a large percentage of the population. Identifying mechanisms …

The involvement of TRPV1 and TRPA1 in mediating craniofacial muscle nociception and
mechanical hyperalgesia was investigated in male Sprague–Dawley rats. First, we …

Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia,
dental pain, and debilitating headaches, affects millions of Americans each year with …

Pain in masticatory muscles is among the most prominent symptoms of temperomandibular
disorders (TMDs) that have diverse and complex etiology. A common complaint of TMD is …

In the trigeminal ganglion (TG), satellite glial cells (SGCs) form a functional unit with
neurons. It has been proposed that SGCs participate in regulating extracellular glutamate …