Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline
ZY Zhang, Z Zhang, U Fauser… - Journal of Cellular and …, 2009 - Wiley Online Library
Experimental autoimmune neuritis (EAN) is a widely used animal model of the human acute
inflammatory demyelinating polyradiculoneuropathy, which is the most common subtype of …
inflammatory demyelinating polyradiculoneuropathy, which is the most common subtype of …
[HTML][HTML] RAD001 (everolimus) attenuates experimental autoimmune neuritis by inhibiting the mTOR pathway, elevating Akt activity and polarizing M2 macrophages
R Han, J Gao, H Zhai, J Xiao, J Hao - Experimental neurology, 2016 - Elsevier
Abstract Guillain–Barre'syndrome (GBS) is an acute, postinfectious, immune-mediated,
demyelinating disease of peripheral nerves and nerve roots. As a classical animal model of …
demyelinating disease of peripheral nerves and nerve roots. As a classical animal model of …
[HTML][HTML] Minocycline relieves neuropathic pain in rats with spinal cord injury via activation of autophagy and suppression of PI3K/Akt/mTOR pathway
L Qiao, Q Tang, Z An, J Qi - Journal of Pharmacological Sciences, 2023 - Elsevier
Objective In this study, we studied whether minocycline hydrochloride improved neuropathic
pain induced by spinal cord injury (SCI) in rats through PI3K/Akt pathway. Methods The SCI …
pain induced by spinal cord injury (SCI) in rats through PI3K/Akt pathway. Methods The SCI …
Minocycline attenuates experimental autoimmune encephalomyelitis in rats by reducing T cell infiltration into the spinal cord
M Nikodemova, JE Lee, Z Fabry, ID Duncan - Journal of neuroimmunology, 2010 - Elsevier
We investigated the anti-inflammatory effects of minocycline in EAE, an animal model of MS.
Minocycline, administered for two weeks after the clinical onset, significantly decreased the …
Minocycline, administered for two weeks after the clinical onset, significantly decreased the …
Nuclear factor kappa B inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type
D Shen, F Chu, Y Lang, C Zheng, C Li… - Clinical & …, 2021 - academic.oup.com
Guillain–Barré syndrome (GBS) is an acute inflammatory and immune-mediated
demyelinating disease of the peripheral nervous system (PNS). Macrophages play a central …
demyelinating disease of the peripheral nervous system (PNS). Macrophages play a central …
[HTML][HTML] The effect of minocycline on motor neuron recovery and neuropathic pain in a rat model of spinal cord injury
DC Cho, JH Cheong, MS Yang, SJ Hwang… - Journal of Korean …, 2011 - ncbi.nlm.nih.gov
Objective Minocycline, a second-generation tetracycline-class antibiotic, has been well
established to exert a neuroprotective effect in animal models and neurodegenerative …
established to exert a neuroprotective effect in animal models and neurodegenerative …
Therapeutic effects of minocycline pretreatment in the locomotor and sensory complications of spinal cord injury in an animal model
K Afshary, M Chamanara, B Talari, P Rezaei… - Journal of Molecular …, 2020 - Springer
Spinal cord injury (SCI) is known as a debilitating condition which usually occurs due to
traumas to the spine. However, the injury could also occur during clinical interventions such …
traumas to the spine. However, the injury could also occur during clinical interventions such …
Spinal versus brain microglial and macrophage activation traits determine the differential neuroinflammatory responses and analgesic effect of minocycline in chronic …
Z Li, H Wei, S Piirainen, Z Chen, E Kalso… - Brain, behavior, and …, 2016 - Elsevier
Substantial evidence indicates involvement of microglia/macrophages in chronic
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …
Doxycycline attenuates peripheral inflammation in rat experimental autoimmune neuritis
C Yi, Z Zhang, W Wang, C Zug, HJ Schluesener… - Neurochemical …, 2011 - Springer
Experimental autoimmune neuritis (EAN) is a T cell-mediated autoimmune inflammatory
demyelinating disease of the peripheral nervous system and widely-used animal model of …
demyelinating disease of the peripheral nervous system and widely-used animal model of …
Minocycline up-regulates the expression of brain-derived neurotrophic factor and nerve growth factor in experimental autoimmune encephalomyelitis
X Chen, L Ma, Y Jiang, S Chen, C Zhu, M Liu… - European journal of …, 2012 - Elsevier
Previous evidence demonstrated that minocycline could ameliorate clinical severity of
experimental autoimmune encephalomyelitis and exhibit several anti-inflammatory and …
experimental autoimmune encephalomyelitis and exhibit several anti-inflammatory and …