Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway

O Uriarte Huarte, D Kyriakis, T Heurtaux… - Frontiers in …, 2021 - frontiersin.org
Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to various pathological stimuli to maintain CNS homeostasis. However, microglial …

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

C Sousa, A Golebiewska, SK Poovathingal… - EMBO …, 2018 - embopress.org
Microglia are specialized parenchymal‐resident phagocytes of the central nervous system
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …

Analyzing microglial phenotypes across neuropathologies: a practical guide

M Schwabenland, W Brück, J Priller, C Stadelmann… - Acta …, 2021 - Springer
As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …

Microglia in health and disease: the strength to be diverse and reactive

O Uriarte Huarte, L Richart, M Mittelbronn… - Frontiers in Cellular …, 2021 - frontiersin.org
Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to any perturbation in order to maintain CNS homeostasis. Although their …

Microglia heterogeneity in health and disease

S Dadwal, MT Heneka - FEBS Open Bio, 2024 - Wiley Online Library
Microglia, the resident immune cells of the central nervous system (CNS), have received
significant attention due to their critical roles in maintaining brain homeostasis and …

A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain

M Olah, V Menon, N Habib, M Taga, C Yung… - BioRxiv, 2018 - biorxiv.org
Recent studies of bulk microglia have provided insights into the role of this immune cell type
in central nervous system development, homeostasis and dysfunction. Nonetheless, our …

Microglia diversity in healthy and diseased brain: insights from single-cell omics

N Ochocka, B Kaminska - International journal of molecular sciences, 2021 - mdpi.com
Microglia are the resident immune cells of the central nervous system (CNS) that have
distinct ontogeny from other tissue macrophages and play a pivotal role in health and …

Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing

M Yaqubi, AMR Groh, MF Dorion, E Afanasiev… - Journal of …, 2023 - Springer
Background Microglia are tissue resident macrophages with a wide range of critically
important functions in central nervous system development and homeostasis. Method In this …

Microglia responses in acute and chronic neurological diseases: what microglia-specific transcriptomic studies taught (and did not teach) us

H E. Hirbec, HN Noristani, FE Perrin - Frontiers in aging neuroscience, 2017 - frontiersin.org
Over the last decade, microglia have been acknowledged to be key players in central
nervous system (CNS) under both physiological and pathological conditions. They …

Organotypic brain slice culture microglia exhibit molecular similarity to acutely-isolated adult microglia and provide a platform to study neuroinflammation

ARD Delbridge, D Huh, M Brickelmaier… - Frontiers in Cellular …, 2020 - frontiersin.org
Microglia are central nervous system (CNS) resident immune cells that have been
implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their …