Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway
O Uriarte Huarte, D Kyriakis, T Heurtaux… - Frontiers in …, 2021 - frontiersin.org
Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to various pathological stimuli to maintain CNS homeostasis. However, microglial …
reacting to various pathological stimuli to maintain CNS homeostasis. However, microglial …
Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
Microglia are specialized parenchymal‐resident phagocytes of the central nervous system
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …
Analyzing microglial phenotypes across neuropathologies: a practical guide
M Schwabenland, W Brück, J Priller, C Stadelmann… - Acta …, 2021 - Springer
As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …
Microglia in health and disease: the strength to be diverse and reactive
O Uriarte Huarte, L Richart, M Mittelbronn… - Frontiers in Cellular …, 2021 - frontiersin.org
Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to any perturbation in order to maintain CNS homeostasis. Although their …
reacting to any perturbation in order to maintain CNS homeostasis. Although their …
Microglia heterogeneity in health and disease
Microglia, the resident immune cells of the central nervous system (CNS), have received
significant attention due to their critical roles in maintaining brain homeostasis and …
significant attention due to their critical roles in maintaining brain homeostasis and …
A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain
Recent studies of bulk microglia have provided insights into the role of this immune cell type
in central nervous system development, homeostasis and dysfunction. Nonetheless, our …
in central nervous system development, homeostasis and dysfunction. Nonetheless, our …
Microglia diversity in healthy and diseased brain: insights from single-cell omics
N Ochocka, B Kaminska - International journal of molecular sciences, 2021 - mdpi.com
Microglia are the resident immune cells of the central nervous system (CNS) that have
distinct ontogeny from other tissue macrophages and play a pivotal role in health and …
distinct ontogeny from other tissue macrophages and play a pivotal role in health and …
Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing
Background Microglia are tissue resident macrophages with a wide range of critically
important functions in central nervous system development and homeostasis. Method In this …
important functions in central nervous system development and homeostasis. Method In this …
Microglia responses in acute and chronic neurological diseases: what microglia-specific transcriptomic studies taught (and did not teach) us
H E. Hirbec, HN Noristani, FE Perrin - Frontiers in aging neuroscience, 2017 - frontiersin.org
Over the last decade, microglia have been acknowledged to be key players in central
nervous system (CNS) under both physiological and pathological conditions. They …
nervous system (CNS) under both physiological and pathological conditions. They …
Organotypic brain slice culture microglia exhibit molecular similarity to acutely-isolated adult microglia and provide a platform to study neuroinflammation
ARD Delbridge, D Huh, M Brickelmaier… - Frontiers in Cellular …, 2020 - frontiersin.org
Microglia are central nervous system (CNS) resident immune cells that have been
implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their …
implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their …