Proteoglycans (PGs) are crucial extracellular matrix (ECM) components that are present in
all tissues and organs. Pathological remodeling of these macromolecules can lead to severe …

Optical technologies hold potential for bio-medical research as well as the clinical routine,
since they allow contact-free, non-destructive access to several clinically relevant features of …

Chondrocyte viability is a crucial factor for evaluating cartilage health. Most prevalent cell
viability assays rely on dyes and are not applicable for in vivo or longitudinal studies. Here …

Objective To evaluate the feasibility of Fourier transform infrared attenuated total reflectance
(FTIR-ATR) spectroscopy to detect cartilage degradation due to osteoarthritis and to validate …

The aim of the study was to optimize preprocessing of sparse infrared spectral data. The
sparse data were obtained by reducing broadband Fourier transform infrared attenuated …

Optical clearing is an effective method to reduce light scattering of biological tissues that
provides significant enhancement of light penetration into the biological tissues making non …

Current tissue engineering approaches for treatment of injured or diseased articular
cartilage use ultraviolet light (UV) for in situ photopolymerization of biomaterials to fill …

Disease or injury to articular cartilage results in loss of extracellular matrix components
which can lead to the development of osteoarthritis (OA). To better understand the process …

This chapter discusses the recent advances in the optical clearing (OC) of cartilage in the
visible and near-infrared (NIR) spectral range. The reduction of natural opacity and …

The application of optical techniques as tools for biomedical research has generated
substantial interest for the ability of such methodologies to simultaneously measure …