Single-stranded oligodeoxynucleotides (ODNs) synthesised to express unmethylated 'CpG
motifs' mimic the ability of bacterial DNA to trigger the innate immune system. CpG ODNs …

Unmethylated CpG motifs in bacterial DNA or short oligodeoxynucleotides (ODN) stimulate
cells of the immune system and provide adjuvant activity. CpG DNA directly activates …

Oligodeoxynucleotides (ODN) containing CpG motifs mimic the ability of microbial DNA to
activate the innate immune system. The resultant response limits the early spread of …

Bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG-motifs in
a particular sequence context activate vertebrate immune cells. We examined the …

Innate immunity provides the first line of defense against invading pathogens and is
essential for survival in the absence of adaptive immune responses. Innate immune …

Since the initial observation that bacterial DNA is recognized by and activates cells of the
immune system (reviewed in 1), substantial progress has been made with respect to the …

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune
adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG …

Over 100 years ago, Coley first explored the use of bacterial products as immunostimulatory
therapy for nonbacterial disease. It is now clear that bacterial DNA, and synthetic …

DNA from bacteria has stimulatory effects on mammalian immune cells,,, which depend on
the presence of unmethylated CpG dinucleotides in the bacterial DNA. In contrast …

Lymphocyte recognition of characteristic structural features in microbial DNA may contribute
to immune defense by promoting protective immune responses. The dinucleotide CpG is …