Transcriptional control of human papillomavirus (HPV) oncogene expression: composition of the HPV type 18 upstream regulatory region

K Butz, F Hoppe-Seyler - Journal of virology, 1993 - Am Soc Microbiol
The malignant transformation potential of high-risk human papillomaviruses (HPVs) is
closely linked to the expression of the viral E6 and E7 genes. To elucidate the molecular …

Activation of human papillomavirus type 18 E6–E7 oncogene expression by transcription factor Sp1

F Hoppe-Seyler, K Butz - Nucleic acids research, 1992 - academic.oup.com
Abstract The human papillomavirus 18 (HPV18) E6 and E7 proteins are considered to be
primarily responsive for the transforming activity of the virus. In order to analyse the …

Genetic Analysis of cis Regulatory Elements within the 5′ Region of the Human Papillomavirus Type 31 Upstream Regulatory Region during Different Stages of the …

E Sen, JL Bromberg-White, C Meyers - Journal of virology, 2002 - Am Soc Microbiol
The function of the 5′ region of the upstream regulatory region (URR) in regulating E6/E7
expression in cancer-associated papillomaviruses has been largely uncharacterized. In this …

The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes

BA Bernard, C Bailly, MC Lenoir, M Darmon… - Journal of …, 1989 - Am Soc Microbiol
The human papillomavirus type 18 (HPV18) long control region (LCR) harbors
transcriptional promoter and enhancer elements. Recombinant plasmids bearing all or part …

Transcriptional activity of human papillomavirus type 31b enhancer is regulated through synergistic interaction of AP1 with two novel cellular factors

S Kyo, A Tam, LA Laimins - Virology, 1995 - Elsevier
Transcription of human papillomaviruses (HPV) is regulated by enhancer sequences
located in the upstream regulatory region. The factors regulating expression of one of the …

During negative regulation of the human papillomavirus-16E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element

SH Tan, B Gloss, HU Bernard - Nucleic acids research, 1992 - academic.oup.com
The principal early promoter of human papillo-maviruses (HPVs), designated P97 in the
case of HPV-16, contains four characteristically aligned cis-responsive elements, namely …

Genetic and Biochemical Analysis of cis Regulatory Elements within the Keratinocyte Enhancer Region of the Human Papillomavirus Type 31 Upstream Regulatory …

E Sen, S Alam, C Meyers - Journal of virology, 2004 - Am Soc Microbiol
Using linker scanning mutational analysis, we recently identified potential cis regulatory
elements contained within the 5′ upstream regulatory region (URR) domain and auxiliary …

The enhancer of human papillomavirus type 16: binding sites for the ubiquitous transcription factors oct-1, NFA, TEF-2, NF1, and AP-1 participate in epithelial cell …

T Chong, D Apt, B Gloss, M Isa, HU Bernard - Journal of Virology, 1991 - Am Soc Microbiol
The enhancer of human papillomavirus type 16 (HPV-16) is considered to be specific for
epithelial cells, in particular for cervical carcinoma-derived cell lines. We reexamined this …

Cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region in transgenic mice and its modulation by tetradecanoyl phorbol acetate and …

A Cid, P Auewarakul, A Garcia-Carranca… - Journal of …, 1993 - Am Soc Microbiol
The upstream regulatory region (URR) of human papillomavirus type 18 (HPV-18) harbors
transcriptional promoter and enhancer elements which are thought to determine the cell …

Many different papillomaviruses have low transcriptional activity in spite of strong epithelial specific enhancers

G Sailaja, RM Watts… - Journal of general …, 1999 - microbiologyresearch.org
Transcription of the E6-E7 genes of human papillomavirus type 11 (HPV-11), HPV-16 and
HPV-18 is specific to epithelial cells. This mechanism originates from synergism between …